FAQs

AMNIOVET™ has a thickness ranging from 50 to 90 μm and its histological structure is comparable to that of the cornea, supporting its use as a protective biological scaffold.
For deep corneal defects, 4 to 10 single layers of AMNIOVET™ may be appropriate.

Histology of fresh amniotic membrane AMNIOVET™.

Histological image of the dog cornea: epithelium (1), stroma (2), Descemet membrane (3) and corneal endothelium (4).

Source: Coyo, N., Leiva, M., Peña, T. The corneal endothelium and its main diseases in the dog. Clinics. Vet. Peq. Anim., 2017, 37 (3): 171-180

AMNIOVET™ provides a structural scaffold designed to support tissue coverage and recovery in ocular surface surgery.

Features:

• Preserves maximum corneal transparency
  • Easy handling: resistant, malleable, adaptable to the corneal surface
  • Thickness suitable for single- and multilayer applications
  • Structural support properties:
• Provides structural support for epithelial coverage and attachment
• Offers protective coverage, maintaining a stable surface during heeling

• Helps preserve the native corneal avascularity by providing a protective covering
• Demonstrates low immunogenicity

AMNIOVET™ can be used either as a protective corneal covering (overlay technique) or as a biological scaffold graft (inlay technique).
As a coating, it acts as a protective covering to maintain surface stability.
As a graft, it provides a natural scaffold to support epithelial coverage.
Both techniques can be combined depending on the clinical situation.

Applications include:

• Anterior stromal ulcers
• Corneal dermoids
• Corneal abduction
• Pigmentary keratitis
• Corneal/intraepithelial neoplasms
• Corneal dystrophies/degeneration
• Deep corneal ulcers
• Corneal perforations
• Collagenase ulcers (melting)
• Indolent ulcers (SCCED)

AMNIOVET™ is available in 40 × 40 mm and 25 × 25 mm sizes.
Each membrane is attached to a nitrocellulose backing, fixed onto a support, and individually packaged in a double sterile polyethylene pouch containing a cryoprotective solution.

AMNIOVET™ can be shipped on request to authorized markets, using isothermal packaging with dry ice and express courier delivery within 24 to 48 hours.

Dry ice or carbonic snow is carbon dioxide (CO2) in solid form. When sublimed, it leaves no moisture residue because its base is not water and its natural state is gaseous. Dry ice is extremely cold and can cause severe frostbite. It is important to handle dry ice with gloves and safety glasses.

Dry ice should be left in a ventilated place as it converts to CO2 on sublimation and there is a risk of asphyxiation.

ATTENTION CONTAINS DRY ICE

• OPEN IN A VENTILATED PLACE.

• AVOID CONTACT WITH SKIN AND EYES.

• WEAR PROTECTIVE GLOVES.

• Do not ingest.
• Cold and pressure can be dangerous.
• Keep out of reach of children.
• Keep in a ventilated place, especially in low areas.
• CO2 has a higher density than air and falls to declining areas.
• Do not handle in basements or enclosed or small rooms.
• Keep container below 50° C.
• Do not seal a container containing dry ice.
• Once the contents have been removed, replace the lid of the UNSEALED container and keep in a well-ventilated place until complete evaporation.
• CO2 gas is non-flammable, odorless and tasteless. Non-toxic.

1. Thaw AMNIOVET® at room temperature for 10 minutes.
2. Open the outer pouch in a sterile environment.

4. The cryopreservative fluid inside the pouch should be collected in a sterile container (e.g., a urine collection jar). If the entire membrane is not used, the remaining fragment may be stored in this container under refrigeration (2–8 °C) for up to 24 hours. DO NOT REFREEZE.

AMNIOVET™ is adhered to the nitrocellulose paper on its stromal side.